FUBP3 Monoclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: MB67176-50, MB67176-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Activation of FUSE, the far-upstream element, is required for the proper expression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP (FUSE-binding protein or far upstream element binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP functions as a growth-dependent regμlator of c-Myc expression. Isolated from proliferating HL60 cells, FBP, FBP2, and FBP3 comprise a family of single-stranded DNAbinding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP is detected in undifferentiated cells and is substantially decreased following cellμlar differentiation. Category: Primary Antibody Reactivity: Human Host: Mouse Applications: WB, IF/ICC Alternate Names: FBP3, Far upstream element-binding protein 3, FUSE-binding protein 3 Clonality: Monoclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: Recombinant fusion protein of human FUBP3. The exact sequence is proprietary. Dilution: WB (1/500 - 1/1000), IF/ICC (1/10 - 1/50) Purification: This antibody is purified through a protein G column. Specificity: Recognizes endogenous levels of FUBP3 protein. Molecular Weight: ~ 62 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: Q96I24 Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide. Research Use Only