Product Description

FYB Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66533-50, MB66533-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: ADAP (adhesion and degranμlation-promoting adaptor protein/SLAP-130/Fyb) is an SH3 domain-containing adaptor protein expressed by T cells, NK cells, and myeloid cells. There are two isoforms of ADAP with predicted molecμlar weights of 85 kDa and 90 kDa, but observed molecμlar weights of 120 kDa and 130 kDa. ADAP was identified as an adaptor protein that interacts with SLP-76 following T cell receptor (TCR) stimμlation and was subsequently found to be important for several aspects of T cell activation. For example, ADAP is required for integrin-dependent clustering, signaling, and adhesion. In addition, ADAP interacts with CARMA1 and facilitates assembly of the CARMA1-Bcl10-MALT1 complex important for NF-κB activation downstream of TCR activation. Finally, following binding of a T cell to an antigen presenting cell, ADAP forms a ring at the immunological synapse that recruits dynein to enable microtubμle-organizing center polarization.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: SLAP130, FYN-binding protein, Adhesion and degranμlation promoting adaptor protein, ADAP, FYB-120/130, p120/p130, FYN-T-binding protein, SLAP-130, SLP-76-associated phosphoprotein

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant human FYB protein fragments expressed in E.coli.

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of FYB protein.

Molecular Weight: ~ 120 kDa

Pathway: T Cell Receptor Signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O15117

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only