Product Description

GA45B Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP09329-20, BT-AP09329-50, BT-AP09329-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.

Research Areas: Cancer; Cell biology; Epigenetics and nuclear signaling; Immunology; Signal transduction

Target Protein: GADD45B

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Growth arrest and DNA damage-inducible protein GADD45 beta

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O75293; Mouse: P22339

Synonyms: Growth arrest and DNA damage-inducible protein GADD45 beta;Myeloid differentiation primary response protein MyD118;Negative growth regulatory protein MyD118

GeneID: Human: 4616

Research Use Only