Product Description

GABAA Rα4 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2387-50, ES2387-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: GABRA4, Gamma-aminobutyric acid receptor subunit alpha-4, GABA(A) receptor subunit alpha-4

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human GABRA4. AA range:81-130

Isotype: IgG

Target: GABA A Receptor α4

Specificity: GABAA Rα4 Polyclonal Antibody detects endogenous levels of GABAA Rα4 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Brain cortex,

Observed Band (KD): 60kD

Fields: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction

Function: Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Induction: The alpha4 beta2 gamma 2L receptor is not repressed by diazepam
Online Information: Forbidden fruit - Issue 56 of March 2005,Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family
Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho

Subcellular Location: Cell junction, synapse, postsynaptic cell membrane, Multi-pass membrane protein Cell membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: GABRA4

Protein Name: Gamma-aminobutyric acid receptor subunit alpha-4

Mouse Gene ID: 14397

Mouse SwissProt Number: Q9D6F4

Rat Gene ID: 140675

Rat SwissProt Number: P28471

Research Use Only