Product Description

GADD 45γ Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2391-50, ES2391-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: GADD45G, CR6, DDIT2, Growth arrest and DNA damage-inducible protein GADD45 gamma, Cytokine-responsive protein CR6, DNA damage-inducible transcript 2 protein, DDIT-2

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human GA45G. AA range:101-150

Isotype: IgG

Target: GADD 45γ

Specificity: GADD 45γ Polyclonal Antibody detects endogenous levels of GADD 45γ protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Colon carcinoma, Lung, Placenta,

Observed Band (KD): 19kD

Fields: MAPK signaling pathway, NF-kappa B signaling pathway, FoxO signaling pathway, Cell cycle, p53 signaling pathway, Apoptosis, Cellular senescence, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Thyroid cancer, Basal cell carcinoma, Melanoma, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer

Function: Function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK
Similarity: Belongs to the GADD45 family
Subunit: Interacts with GADD45GIP1

Subcellular Location: nucleus, cytoplasm,

Storage and Stability: -20°C/1 year

Gene Name: GADD45G

Protein Name: Growth arrest and DNA damage-inducible protein GADD45 gamma

Mouse SwissProt Number: Q9Z111

Rat Gene ID: 291005

Rat SwissProt Number: Q9WTQ7

Research Use Only