GCK Monoclonal Antibody - BT-MCA4625

GCK Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4625-50, BT-MCA4625-100

Citations, Manuals and MSDS Available upon request.

Background: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Research Areas: Signal Transduction, Metabolism

Target Protein: GCK

Reactivity: Human

Clonality: Monoclonal

Clone ID: 4G6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: GCK

Immunogen: Purified recombinant fragment of human GCK expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 52kDa

UniProt Accession: P35557

Synonyms: GK, GLK, HK4, HHF3, HKIV, HXKP, LGLK, MODY2, FGQTL3

GeneID: 2645

Research Use Only