GFI1 Monoclonal Antibody - BT-MCA2223

GFI1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2223-50, BT-MCA2223-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.Expression of GFl1 ranges from the hematopoietic and lymphoid system, to sensory epithelia, lung and parts of the CNS.

Research Areas: Tags and, cell markers

Target Protein: GFI1

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5D7

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: GFI1

Immunogen: Purified recombinant fragment of human GFI1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 45kDa

UniProt Accession: Q99684

Synonyms: SCN2, GFI-1, ZNF163, FLJ94509, GFI1

GeneID: 2672

Research Use Only