Product Description

GLRX3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS8084-50, BS8084-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: PICOT, also known as GLRX3 (glutaredoxin 3), GRX3, GRX4, GLRX4, HUSSY-22, TXNL2 or TXNL3, is a 335 amino acid protein that contains one thioredoxin domain and two glutaredoxin domains. Localized to the cytoplasm and the cell cortex, PICOT is thought to play a role in regμlating the thioredoxin system and may weakly interact with PKC θ (protein kinase C theta). Through its ability to regμlate the thioredoxin pathway, PICOT inhibits cardiac hypertrophy (a thickening of the heart muscle usually caused by high blood pressure) by negatively regμlating NFAT (Nuclear factor of activated T-cells) signaling. Although PICOT contains one thioredoxin domain, it lacks the two redox-reactive cysteines that are required for catalytic activity, suggesting that PICOT lacks thioredoxin function. PICOT is expressed in testis, heart and spleen with lower levels detected in thymus, lung, colon, placenta and small intestine.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: Glutaredoxin-3, PKC-interacting cousin of thioredoxin, PICOT, PKC-theta-interacting protein, PKCq-interacting protein, Thioredoxin-like protein 2, GLRX3, PICOT, TXNL2, HUSSY-22

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human GLRX3.

Dilution: WB 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: GLRX3 polyclonal antibody detects endogenous levels of GLRX3 protein.

Molecular Weight: ~ 37 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O76003

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only