GPR30 Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS65862-50, BS65862-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: G protein-coupled receptors (GPRs, or GPCRs) contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellμlar loops and transduce a variety of hormone, endogenous peptide, and neurotransmitter signals into intracellμlar effects via G proteins. GRP30 is a member of this family and is an orphan receptor. GPR30 expression has been reported in brain, breast carcinoma, blood, bone marrow, CNS, heart, liver, lung, lymph node, placenta, and spleen. In brain, GPR30 is expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen. However, unlike other known G protein-coupled receptors, GPR30 localizes to the endoplasmic reticμlum, where it specifically binds estrogen and estrogen derivatives. Category: Primary Antibody Reactivity: Human, Mouse, Rat, Dog Host: Rabbit Applications: WB, IHC-P Alternate Names: G Protein Coupled Receptor 30, G-protein coupled receptor 30, G-protein coupled estrogen receptor 1, Membrane estrogen receptor, mER, Chemokine receptor-like 2, IL8-related receptor DRY12, Flow-induced endothelial G-protein coupled receptor 1, FEG-1, Lymphocyte-derived G-protein coupled receptor, LYGPR, GPCR-BR, CEPR, CMKRL2, DRY12, GPER. Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH conjugated synthetic peptide derived from human GPR30:251-350/375 Dilution: WB=1:500-2000 IHC-P=1:100-500 Purification: affinity purified by Protein A Specificity: GPR30 Polyclonal Antibody detects endogenous levels of GPR30 protein. Molecular Weight: ~55 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -35°C long term. Avoid freeze-thaw cycles. SwissProt: Q99527 Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Research Use Only