Product Description

GPX3 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP09706-20, BT-AP09706-50, BT-AP09706-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3andapos; UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designa

Research Areas: Cancer; Cell biology; Metabolism; Signal transduction

Target Protein: GPX3

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Glutathione peroxidase 3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P22352; Mouse: P46412; Rat: P23764

Synonyms: Glutathione peroxidase 3;GPx-3;GSHPx-3;EC 1.11.1.9;Extracellular glutathione peroxidase;Plasma glutathione peroxidase;GPx-P;GSHPx-P

GeneID: Human: 2878

Research Use Only