GRK 2 Monoclonal Antibody - BT-MCA0630

GRK 2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0630-50, BT-MCA0630-100

Citations, Manuals and MSDS Available upon request.

Background: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Research Areas: Signal transduction; Neuroscience

Target Protein: ADRBK1

Applications: WB, IHC-p, IF, ICC, ELISA

Reactivity: Human,Mouse,Rat,Monkey

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Beta-adrenergic receptor kinase 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P25098; Mouse: Q99MK8; Rat: P26817

Synonyms: ADRBK1; BARK; BARK1; GRK2; Beta-adrenergic receptor kinase 1; Beta-ARK-1; G-protein coupled receptor kinase 2

GeneID: Human: 15625238

Research Use Only