GSK3 alpha Monoclonal Antibody - BT-MCA3051

GSK3 alpha Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3051-50, BT-MCA3051-100

Citations, Manuals and MSDS Available upon request.

Background: Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily,GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

Research Areas: Others

Target Protein: GSK3 alpha

Applications: WB

Reactivity: Human

Clonality: Monoclonal

Clone ID: 6G12C2

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: GSK3 alpha

Immunogen: Purified recombinant fragment of GSK3 alpha expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P49840

Synonyms: DKFZp686D0638, GSK3A

GeneID: 2931

Research Use Only