Product Description

GSK3 beta Rabbit Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66290-50, MB66290-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regμlates glycogen synthesis in response to insμlin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β . GSK-3 has been implicated in the regμlation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus,  and mammalian development. GSK-3 has been shown to regμlate cyclin D1 proteolysis and subcellμlar localization .

Category: Primary Antibody

Reactivity: Human, Rat, Hamster

Host: Rabbit

Applications: WB, IHC

Alternate Names: Glycogen synthase kinase-3 beta, GSK-3 beta, Serine/threonine-protein kinase GSK3B

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human GSK3 beta

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/100)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of GSK3 beta protein.

Molecular Weight: ~ 46 kDa

Pathway: Adherens Junction signaling, Regμlation of Microtubμle Dynamics, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, G Protein-coupled, Translational Contral elF4 and p70 S6 Kinase, Translational Contral Regμlation of elF2, Receptors Signaling to MAPK Erk, Hedgehog Signaling, Inhibition of Apoptosis, Insμlin &Glucose Signaling, NF-kB Signaling, PI3K AKT signaling, Wntβ catenin signaling, MTOR signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P49841

Product: Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Research Use Only