GSK3B Monoclonal Antibody - BT-MCA3458

GSK3B Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3458-50, BT-MCA3458-100

Citations, Manuals and MSDS Available upon request.

Background: Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transduction cascade of a large number of growth factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt: Akt-mediated phosphorylation at Ser21 of GSK-3a and Ser9 of GSK-3

Research Areas: Neuroscience

Target Protein: GSK3B

Applications: WB, IHC, ICC, FCM

Reactivity: Human, Mouse, Monkey, Rat

Clonality: Monoclonal

Clone ID: 3D10

Host: Mouse

Isotype: Mouse IgG2a

Full Product Name: GSK3B

Immunogen: Purified recombinant fragment of human GSK3B expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 46kDa

UniProt Accession: P49841

Synonyms: GSK-3β, GSK3-beta

GeneID: 2932

Research Use Only