GSTM1 Polyclonal Antibody Sizes: 60μL, 120μL, 200μL Catalogue Numbers: E-AB-91795-60, E-AB-91795-120, E-AB-91795-200 Citations, Manuals and MSDS Available upon request. Abbreviation: GSTM1 Target Synonym: GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GTM1; H-B; MU; MU-1; GSTM1 Research Areas: Tags & Cell Markers,Signal Transduction,Metabolism Conjugation: Unconjugated Host: Rabbit Species Reactivity: Human, Mouse, Rat Application: WB Isotype: IgG Clonality: Polyclonal UNIProt ID: P09488 Background: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] Concentration: 1mg/mL Immunogen: Recombinant fusion protein of human GSTM1 Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3. Purification Method: Affinity purification Dilution: WB 1:500-1:2000 Calculated MW: 21kDa/25kDa Observed MW: 28KDa Storage: -20°C/One year. Avoid freeze / thaw cycles. Shipping: Ice bag Research Use Only