GTBP Monoclonal Antibody - BT-MCA0646

GTBP Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0646-50, BT-MCA0646-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

Research Areas: Epigenetics and nuclear signaling

Target Protein: MSH6

Applications: WB, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: DNA mismatch repair protein Msh6

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P52701; Mouse: P54276

Synonyms: MSH6; GTBP; DNA mismatch repair protein Msh6; hMSH6; G; T mismatch-binding protein; GTBP; GTMBP; MutS-alpha 160 kDa subunit; p160

GeneID: Human: 2956

Research Use Only