Product Description

GUC1A Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES15854-50, ES15854-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes an enzyme that plays a role in the recovery of retinal photoreceptors from photobleaching. This enzyme promotes the activity of retinal guanylyl cyclase-1 (GC1) at low calcium concentrations and inhibits GC1 at high calcium concentrations. Mutations in this gene can cause cone dystrophy 3 and code-rod dystrophy 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human GUC1A AA range: 63-113

Isotype: IgG

Target: GUC1A

Specificity: This antibody detects endogenous levels of GUC1A at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: In the retina, it is expressed in rod and cone photoreceptors,

Molecular Weight (Da): 22kD

Fields: Phototransduction

Function: Disease: Defects in GUCA1A are the cause of cone dystrophy type 3 (COD3) [MIM: 602093]. COD3 is an autosomal dominant cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies, in which some loss of peripheral vision also occurs
Function: Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a

Subcellular Location: Membrane, Lipid-anchor Photoreceptor inner segment Cell projection, cilium, photoreceptor outer segment Present at higher levels in cone than in rod outer segments (PubMed:9620085) Subcellular location is not affected by light or dark conditions

Storage and Stability: -20°C/1 year

Gene Name: GUCA1A C6orf131 GCAP GCAP1 GUCA1

Protein Name: GUC1A

Mouse Gene ID: 14913

Mouse SwissProt Number: P43081

Research Use Only