Product Description

H2AV Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES15848-50, ES15848-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. [provided by RefSeq, Oct 2015],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human H2AV AA range: 27-77

Isotype: IgG

Target: H2AV

Specificity: This antibody detects endogenous levels of H2AV at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 14kD

Fields: Necroptosis, Neutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus

Function: Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division
mass spectrometry: Monoisotopic, not modified PubMed: 16457589,PTM: Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disa

Subcellular Location: Nucleus Chromosome

Storage and Stability: -20°C/1 year

Gene Name: H2AFV H2AV

Protein Name: H2AV

Mouse Gene ID: 77605

Mouse SwissProt Number: Q3THW5

Research Use Only