HAS1 Monoclonal Antibody - BT-MCA2712

HAS1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2712-50, BT-MCA2712-100

Citations, Manuals and MSDS Available upon request.

Background: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Research Areas: Signal transduction, Neuroscience, Developmental biology, Cardiovascular

Target Protein: HAS1

Applications: ICC, FCM

Clonality: Monoclonal

Clone ID: 5B5B4

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: HAS1

Immunogen: Purified recombinant fragment of human HAS1 (AA: (74-399)) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 65kDa

UniProt Accession: Q92839

Synonyms: HAS

GeneID: 3036

Research Use Only