HAS2 Monoclonal Antibody - BT-MCA2439

HAS2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2439-50, BT-MCA2439-100

Citations, Manuals and MSDS Available upon request.

Background: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Research Areas: Others

Target Protein: HAS2

Applications: WB, IHC, ICC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 4E7

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: HAS2

Immunogen: Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 63.5kDa

UniProt Accession: Q92819

GeneID: 3037

Research Use Only