HBEGF Polyclonal Antibody - BT-AP09826

HBEGF Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP09826-20, BT-AP09826-50, BT-AP09826-100

Citations, Manuals and MSDS Available upon request.

Background: May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.,PTM:O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937).,PTM:Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.,Contains 1 EGF-like domain.,subcellular location:Mature HB-EGF is released into the extracellular space and probably binds to a receptor.,

Research Areas: Cancer; Cardiovascular; Signal transduction

Target Protein: HBEGF

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q99075; Mouse: Q06186; Rat: Q06175

Synonyms: Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor;HB-EGF;HBEGF;Diphtheria toxin receptor;DT-R]

GeneID: Human: 1839

Research Use Only