HDAC3 Monoclonal Antibody - BT-MCA0669

HDAC3 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0669-50, BT-MCA0669-100

Citations, Manuals and MSDS Available upon request.

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Research Areas: Epigenetics and nuclear signaling; Stem cells; Cancer; Metabolism

Target Protein: HDAC3

Applications: WB

Reactivity: Human,Mouse,Rat,Dog,Pig,Rabbit

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Histone deacetylase 3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O15379; Mouse: O88895; Rat: Q6P6W3

Synonyms: HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45

GeneID: Human: 884184578

Research Use Only