Product Description

HECW1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP09859-20, BT-AP09859-50, BT-AP09859-100

Citations, Manuals and MSDS Available upon request.

Background: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.,pathway:Protein modification; protein ubiquitination.,Contains 1 C2 domain.,Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,Contains 2 WW domains.,subunit:Interacts with DVL1 and SSR3. Also interacts with mutant SOD1.,tissue specificity:Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.,

Research Areas: Cell biology; Epigenetics and nuclear signaling; Neuroscience

Target Protein: HECW1

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: E3 ubiquitin-protein ligase HECW1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q76N89; Mouse: Q8K4P8

Synonyms: E3 ubiquitin-protein ligase HECW1;EC 6.3.2.-;HECT, C2 and WW domain-containing protein 1;NEDD4-like E3 ubiquitin-protein ligase 1;hNEDL1

GeneID: Human: 23072

Research Use Only