Hel-N1 (N86) Polyclonal Antibody-BS1966

Hel-N1 (N86) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS1966-50, BS1966-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q12926

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM), and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Hel-N1 (N86) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 40 kDa

Specificity: Hel-N1 (N86) polyclonal antibody detects endogenous levels of HuB protein, and also detects HuD protein

Alternative Name: ELAV like 4; ELAV like neuronal protein 1; ELAV like protein 2; ELAV like protein 4; ELAVL 2; ELAVL 4; HELN1; Hu antigen B; Hu antigen D; HUB; HUD; Hel-N1; ELAVL2; HEL-N1; HELN1; HUB

Immunogen: Synthetic peptide, corresponding to amino acids 50-100 of Human Hel-N1.

Conjugate: Unconjugated

Modification: Unmodified