Product Description

HEPS Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11189-50, ES11189-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 350-430

Isotype: IgG

Target: HEPS

Specificity: HEPS Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Detected in liver and kidney,

Observed Band (KD): 45kD

Fields: Viral carcinogenesis

Function: Catalytic Activity: Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys
Function: Plays an essential role in cell growth and maintenance of cell morphology
Similarity: Belongs to the peptidase S1 family
Similarity: Contains 1 peptidase S1 domain
Similarity: Contains 1 SRCR domain
Tissue Specificity: Present in most tissues, with the highest level in liver

Subcellular Location: Cell membrane, Single-pass type II membrane protein Apical cell membrane, Single-pass type II membrane protein

Storage and Stability: -20°C/1 year

Gene Name: HPN TMPRSS1

Protein Name: Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain, Serine protease hepsin catalytic chain]

Mouse SwissProt Number: O35453

Rat SwissProt Number: Q05511

Research Use Only