Product Description

HES3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10582-50, ES10582-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 20-100

Isotype: IgG

Target: HES3

Specificity: HES3 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Observed Band (KD): 20kD

Fields: Human papillomavirus infection

Function: Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG)
Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins
Function: Transcriptional repressor of genes that require a bHLH protein for their transcription
Similarity: Contains 1 basic helix-loop-helix (bHLH) domain
Similarity: Contains 1 Orange domain
Subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: HES3 BHLHB43

Protein Name: Transcription factor HES-3 (Class B basic helix-loop-helix protein 43) (bHLHb43) (Hairy and enhancer of split 3)

Mouse SwissProt Number: Q61657

Rat SwissProt Number: Q04667

Research Use Only