HIPK3 Polyclonal Antibody - BT-AP09897

HIPK3 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP09897-20, BT-AP09897-50, BT-AP09897-100

Citations, Manuals and MSDS Available upon request.

Background: Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.,PTM:Autophosphorylated, but autophosphorylation is not required for Catalytic activity.,PTM:May be sumoylated.,Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.,Contains 1 protein kinase domain.,subunit:Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1.,tissue specificity:Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.,

Research Areas: Cell biology; Epigenetics and nuclear signaling; Signal transduction

Target Protein: HIPK3

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Homeodomain-interacting protein kinase 3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9H422; Mouse: Q9ERH7; Rat: O88850

Synonyms: Homeodomain-interacting protein kinase 3;EC 2.7.11.1;Androgen receptor-interacting nuclear protein kinase;ANPK;Fas-interacting serine/threonine-protein kinase;FIST;Homolog of protein kinase

GeneID: Human: 10114

Research Use Only