Product Description

Histone H1 (Tri Methyl Lys25) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES20561-50, ES20561-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015],

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: H1K25ME3, HIST1H1A, H1F1, Histone H1.1, Histone H1a, HIST1H1C, H1F2, Histone H1.2, Histone H1c, Histone H1d, Histone H1s-1, HIST1H1D, H1F3, Histone H1.3, Histone H1c, Histone H1s-2, HIST1H1E, H1F4, Histone H1.4, Histone H1b, Histone H1s-4

Clonality: Polyclonal

Immunogen: Synthetic Peptide of Histone H1 (Tri Methyl Lys25)

Isotype: IgG

Target: Histone H1

Specificity: The antibody detects endogenous Histone H1 (Tri Methyl Lys25) protein.

Dilution: WB: 1:1000-2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.

Formlation: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Expression: Placenta,

Observed Band (KD): 17-25kD

Function: Function: Histones H1 are necessary for the condensation of nucleosome chains into higher order structures
Similarity: Belongs to the histone H1/H5 family

Subcellular Location: Nucleus Chromosome Mainly localizes in euchromatin

Storage and Stability: -20°C/1 year

Gene Name: HIST1H1A/HIST1H1C/HIST1H1D/HIST1H1E

Protein Name: Histone H1.1/Histone H1.2/Histone H1.3/Histone H1.4

Mouse Gene ID: 80838/50708/14957/50709

Rat Gene ID: 291145/201097

Rat SwissProt Number: D4A3K5/P15865

Research Use Only