Histone H2A.Z Polyclonal Antibody - BT-AP04008

Histone H2A.Z Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP04008-20, BT-AP04008-50, BT-AP04008-100

Citations, Manuals and MSDS Available upon request.

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. H2AFZ encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: H2AFZ

Applications: WB

Reactivity: Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Histone H2A.Z Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 51633

UniProt Accession: Human: P0C0S5; Mouse: P0C0S6; Rat: P0C0S7

Synonyms: H2AFZ; H2AZ; Histone H2A.Z; H2A/z

GeneID: Human: 3015; Mouse: 51788; Rat: 58940

Research Use Only