Product Description

Histone H3 (Acetyl-K123) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS64086-50, BS64086-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Chromatin is the arrangement of DNA and proteins in which chromosomes are formed. Correspondingly, chromatin is formed from nucleosomes, which are comprised of a set of four histone proteins (H2A, H2B, H3, H4) wrapped with DNA. Chromatin is a very dynamic structure in which numerous post-translational modifications work together to activate or repress the availability of DNA to be copied, transcribed, or repaired. These marks decide which DNA will be open and commonly active (euchromatin) or tightly wound to prevent access and activation (heterochromatin). Common histone modifications include methylation of lysine and arginine, acetylation of lysine, phosphorylation of threonine and serine, and sumoylation, biotinylation, and ubiquitylation of lysine.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Histone H3.1, Histone H3A, H3FA, Histone H3B, H3FL, Histone H3C, H3FC, Histone H3D, H3FB, Histone H3E, H3FD, Histone H3F, H3FI, Histone H3G, H3FH, Histone H3H, H3FK, Histone H3I, H3FF, Histone H3J, H3FJ, Histone H3.2, Histone H3/m, Histone H3/o, HIST2H3A, HIST2H3C, H3F2, H3FM, HIST2H3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Acetylated

Immunogen: Synthetic peptide derived from human Histone H3 around the acetylated at Lys123.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Specificity: Ac-Histone H3 (K123) polyclonal antibody detects endogenous levels of Histone H3 protein only when acetylated at Lys123.

Molecular Weight: ~ 14 kDa

Pathway: Histone Lysine Methylation Pathway, Examples of Crosstalk Between Post-translational Modifications, DNA Methylation,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P68431/Q71DI3/P84243/Q6NXT2

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only