HLA-DPB1 Monoclonal Antibody - BT-MCA3372

HLA-DPB1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3372-50, BT-MCA3372-100

Citations, Manuals and MSDS Available upon request.

Background: HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Research Areas: Others

Target Protein: HLA-DPB1

Applications: IHC, FCM

Reactivity: Human, Rat

Clonality: Monoclonal

Clone ID: 5C9F4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: HLA-DPB1

Immunogen: Purified recombinant fragment of human HLA-DPB1 (AA: extra 30-215) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 29.2kDa

UniProt Accession: P04440

Synonyms: DPB1, HLA-DP, HLA-DPB, HLA-DP1B

GeneID: 3115

Research Use Only