HLA-DRB1 Monoclonal Antibody - BT-MCA4330

HLA-DRB1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4330-50, BT-MCA4330-100

Citations, Manuals and MSDS Available upon request.

Background: HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Research Areas: Immunology

Target Protein: HLA-DRB1

Applications: IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5B3D2

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: HLA-DRB1

Immunogen: Purified recombinant fragment of human HLA-DRB1 (AA: 30-266) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 29.9kDa

UniProt Accession: P01911

Synonyms: SS1, DRB1, HLA-DRB, HLA-DR1B

GeneID: 3123

Research Use Only