HORMAD2 Polyclonal Antibody - E-AB-19220

HORMAD2 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-19220-60, E-AB-19220-120, E-AB-19220-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: HORMAD2

Target Synonym: 4930529M09Rik; CT46.2; HORM2; HORMA domain containing 2; HORMA domain-containing protein 2; Hormad2; MGC26710; RP23-329P17.4

Research Areas: Cell Biology

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q8N7B1

Background: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity).

Concentration: 1.32 mg/mL

Immunogen: Fusion protein of human HORMAD2

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:50-1:200, ELISA 1:5000-1:10000

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only