Product Description

HoxA11/D11 (Y248) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1977-50, BS1977-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The homeobox gene HOXA11, also designated homeobox 1I (HOX1I), belongs to the AbdB homeobox family. HoxA11 is necessary for fertility in females as it is a regμlator of the cyclic development of the adμlt endometrium and embryonic uterine development. The expression of HoxA11 increases drastically during the midluteal stage of the menstrual cycle, which is necessary for implantation of the blastocyst. HoxD11 (homeobox D11), also known as HOX4 or HOX4F, is a 338 amino acid protein that contains one homeobox DNA-binding domain and is a member of the Abd-B homeobox family. Localized to the nucleus, HoxD11 functions as a sequencespecific transcription factor that, in conjunction with a variety of other proteins, provides cells with positional identities on their anterior-posterior axis. Defects in the gene encoding HoxD11 are associated with severe limb and genital abnormalities, suggesting that HoxD11 plays an important role in forelimb morphogenesis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Homeobox protein Hox-A11, Homeobox protein Hox-1I, HOXA11, HOX1I, Homeobox protein Hox-D11, Homeobox protein Hox-4F, HOXD11, HOX4F

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 200-250 of Human Hox-A11.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: HoxA11/D11 (Y248) polyclonal antibody detects endogenous levels of HoxA11 and HoxD11 protein.

Molecular Weight: ~ 30 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P31270/P31277

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only