HP1Alpha Polyclonal Antibody - BT-AP04200

HP1Alpha Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP04200-20, BT-AP04200-50, BT-AP04200-100

Citations, Manuals and MSDS Available upon request.

Background: CBX5 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. Chromobox protein homolog 5 is enriched in the heterochromatin and associated with centromeres. Chromobox protein homolog 5 has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. Chromobox protein homolog 5 is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: CBX5

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: HP1alpha Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 22225

UniProt Accession: Human: P45973; Mouse: Q61686

Synonyms: CBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha

GeneID: Human: 23468; Mouse: 12419

Research Use Only