Product Description

HSP 90 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4057-50, ES4057-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: HSP90AA1; HSP90A; HSPC1; HSPCA; Heat shock protein HSP 90-alpha; Heat shock 86 kDa; HSP 86; HSP86; Renal carcinoma antigen NY-REN-38; HSP90AB1; HSP90B; HSPC2; HSPCB; Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP84

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human HSP90A/B around the non-acetylation site of Lys292/284. AA range:251-300

Isotype: IgG

Target: HSP 90,

Specificity: HSP 90 Polyclonal Antibody detects endogenous levels of HSP 90 protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Adult brain, Brain, Brain cortex, Breast, Cajal-Retzius

Observed Band (KD): 85kD

Fields: Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Necroptosis, Antigen processing and presentation, NOD-like receptor signaling pathway, IL-17 signaling pathway, Th17 cell differentiation, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Salmonella infection, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis

Function: Caution: Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence. Molecular chaperone. Molecular chaperone. Has ATPase activity. Similarity: Belongs to the heat shock protein 90 family. Subcellular Location: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Subunit: Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.

Subcellular Location: Nucleus Cytoplasm Melanosome Cell membrane Mitochondrion Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Storage and Stability: -20°C/1 year

Gene Name: HSP90AA1/HSP90AB1

Protein Name: Heat shock protein HSP 90-alpha/Heat shock protein HSP 90-beta

Human Gene ID: 3326

Human SwissProt Number: P07900

Mouse Gene ID: 15519

Mouse SwissProt Number: P07901

Rat Gene ID: 299331

Rat SwissProt Number: P82995

Research Use Only