Product Description

HSP27 (Phospho S78/82) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES15594-50, ES15594-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Heat shock protein beta-1 (HspB1, 28 kDa heat shock protein, Estrogen-regulated 24 kDa protein, Heat shock 27 kDa protein, HSP 27, Stress-responsive protein 27, SRP27)

Clonality: Polyclonal

Immunogen: Synthesized pospho peptide derived from human HSP27 (Phospho S78/82)

Isotype: IgG

Target: HSP27

Specificity: This antibody detects endogenous pospho levels of human HSP27 (Phospho S78/82)

Dilution: WB 1:500-2000, ELISA(peptide)1:5000-20000

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid, Highest levels are found in the heart and in tissues composed of striated and smooth muscle,

Observed Band (KD): 27kD

Fields: MAPK signaling pathway, VEGF signaling pathway, Amoebiasis

Function: Disease: Defects in HSPB1 are a cause of distal hereditary motor neuronopathy type 2B (HMN2B) [MIM: 608634]. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective impairment of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs
Disease: Defects in HSPB1 are the cause of Charcot-Marie-Tooth disease type 2F (CMT2F) [MIM: 606595]. CMT2F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of

Subcellular Location: Cytoplasm Nucleus Cytoplasm, cytoskeleton, spindle Cytoplasmic in interphase cells Colocalizes with mitotic spindles in mitotic cells Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles

Storage and Stability: -20°C/1 year

Gene Name: HSPB1 HSP27 HSP28

Protein Name: HSP27 (Phospho S78/82)

Research Use Only