Human P16 Monoclonal Antibody - BT-MCA3472

Human P16 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3472-50, BT-MCA3472-100

Citations, Manuals and MSDS Available upon request.

Background: p16 (cyclin-dependent kinase inhibitor 2A, INK4a) is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 / Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16 INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.

Research Areas: Others

Target Protein: Human P16

Applications: IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5A8A4; 3G8D12

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: Human P16

Immunogen: Purified recombinant fragment of P16 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P42771

Synonyms: Human P16

GeneID: 1029

Research Use Only