Product Description

IκB-β Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES6385-50, ES6385-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC

Alternate Names: NFKBIB, IKBB, TRIP9, NF-kappa-B inhibitor beta, NF-kappa-BIB, I-kappa-B-beta, IkB-B, IkB-beta, IkappaBbeta, Thyroid receptor-interacting protein 9, TR-interacting protein 9, TRIP-9

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human IkappaB-beta. AA range:4-53

Isotype: IgG

Target: IκB β

Specificity: IκB-β Polyclonal Antibody detects endogenous levels of IκB-β protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in all tissues examined,

Observed Band (KD): 37kD

Fields: Chemokine signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Neurotrophin signaling pathway, Adipocytokine signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Leishmaniasis, Toxoplasmosis, Measles, Influenza A, Epstein-Barr virus infection, Coronavirus disease - COVID-19, PD-L1 expression and PD-1 checkpoint pathway in cancer

Function: Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation
PTM: Phosphorylated, followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation
Similarity: Belongs to the NF-kappa-B inhibitor family
Similarity: Contains 6 ANK repeats
Subunit: Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2
Tissue Specificity: Expressed in all tissues examined

Subcellular Location: Cytoplasm Nucleus

Storage and Stability: -20°C/1 year

Gene Name: NFKBIB

Protein Name: NF-kappa-B inhibitor beta

Mouse Gene ID: 18036

Mouse SwissProt Number: Q60778

Research Use Only