IDH2 Monoclonal Antibody - BT-MCA4722

IDH2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4722-50, BT-MCA4722-100

Citations, Manuals and MSDS Available upon request.

Background: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Research Areas: Cancer, Metabolism, Signal transduction

Target Protein: IDH2

Applications: IHC, FCM

Clonality: Monoclonal

Clone ID: 3E8D12

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: IDH2

Immunogen: Purified recombinant fragment of human IDH2 (AA: 1-143) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 50.9kDa

UniProt Accession: P48735

Synonyms: IDH, IDP, IDHM, IDPM, ICD-M, D2HGA2, mNADP-IDH

GeneID: 3418

Research Use Only