IFN-gamma Monoclonal Antibody - BT-MCA4532

IFN-gamma Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4532-50, BT-MCA4532-100

Citations, Manuals and MSDS Available upon request.

Background: IFN-gamma (interferon, gamma) is an antiviral and antiparasitic agent produced by CD4+/CD8+ lymphocytes and natural killer cells that undergo activation by antigens, mitogens or alloantigens. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses, including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. The active form of IFN-G is a homodimer with each subunit containing six helices. The dimeric structure of human IFN-G is stabilized by non-covalent interactions through the interface of the helices. IFN-G translated precursor is 166 amino acids, including the 23 amino acid secretory sequence. It is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. Multiple forms exist due to variable glycosylation and under non-denaturing conditions due to dimers and tetramers.

Research Areas: Others

Target Protein: IFN-gamma

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1B1A4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: IFN-gamma

Immunogen: Recombinant human IFN-gamma (BioSource company, Cat.No. PHC4033)

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P01579

Synonyms: IFG, IFI, IFNG

GeneID: 3458

Research Use Only