IGF1R-Beta Monoclonal Antibody - BT-MCA2601

IGF1R-Beta Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2601-50, BT-MCA2601-100

Citations, Manuals and MSDS Available upon request.

Background: IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.

Research Areas: Others

Target Protein: IGF1R-Beta

Applications: IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3G5C1

Host: Mouse

Isotype: Mouse IgG2a

Full Product Name: IGF1R-Beta

Immunogen: Purified recombinant fragment of IGF1R-Beta (AA: 1101-1367) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 96kDa

UniProt Accession: P08069

Synonyms: IGF1R

GeneID: 3480

Research Use Only