Product Description

IKB alpha Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66946-50, MB66946-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins . Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that resμlts in the release and nuclear translocation of active NF-κB . IκBα phosphorylation and resμlting Rel-dependent transcription are activated by a highly diverse group of extracellμlar signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major histocompatibility complex enhancer-binding protein MAD3

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human IKB alpha. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of IKB alpha protein.

Molecular Weight: ~ 35 kDa

Pathway: Regμlation of Apoptosis, B Cell Receptor Signaling, Death Receptor Signaling, MAPK Erk in Growth and Differentiation Pathway, Inhibition of Apoptosis, NF-kB Signaling, T cell receptor signaling, Toll-like Receptor signaling.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P25963

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only