IKBKB Monoclonal Antibody - BT-MCA2844

IKBKB Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2844-50, BT-MCA2844-100

Citations, Manuals and MSDS Available upon request.

Background: IKBKB(Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.

Research Areas: Cell Biology

Target Protein: IKBKB

Applications: IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 10A2C5B3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: IKBKB

Immunogen: Purified recombinant fragment of IKBKB expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: O14920

Synonyms: IKBKB

GeneID: 3551

Research Use Only