IKZF1 Monoclonal Antibody - BT-MCA3783

IKZF1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3783-50, BT-MCA3783-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Research Areas: Signal transduction, Cancer

Target Protein: IKZF1

Applications: ICC, FCM

Clonality: Monoclonal

Clone ID: 1C1B6

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: IKZF1

Immunogen: Purified recombinant fragment of human IKZF1 (AA: 401-520) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 57.5kDa

UniProt Accession: Q13422

Synonyms: IK1, LYF1, LyF-1, CVID13, IKAROS, PPP1R92, PRO0758, ZNFN1A1, Hs.54452

GeneID: 10320

Research Use Only