IL-10RAlpha Polyclonal Antibody - BT-AP04431

IL-10RAlpha Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP04431-20, BT-AP04431-50, BT-AP04431-100

Citations, Manuals and MSDS Available upon request.

Background: Interleukin-10 receptor subunit alpha encoded by IL10RA is a receptor for interleukin 10. Interleukin-10 receptor subunit alpha is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

Research Areas: Immunology

Target Protein: IL10RA

Applications: WB, IF, ELISA

Reactivity: Human

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: IL-10Ralpha Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 62904

UniProt Accession: Human: Q13651; Mouse: Q61727

Synonyms: IL10RA; IL10R; Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD antigen CD2

GeneID: Human: 3587

Research Use Only