Product Description

IL-13Rα1 (phospho Tyr405) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES5896-50, ES5896-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF, ELISA

Alternate Names: IL13RA1, IL13R, IL13RA, Interleukin-13 receptor subunit alpha-1, IL-13 receptor subunit alpha-1, IL-13R subunit alpha-1, IL-13R-alpha-1, IL-13RA1, Cancer/testis antigen 19, CT19, CD antigen CD213a1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human IL-13R alpha1 around the phosphorylation site of Tyr405. AA range:371-420

Isotype: IgG

Target: IL-13Rα1

Specificity: Phospho-IL-13Rα1 (Y405) Polyclonal Antibody detects endogenous levels of IL-13Rα1 protein only when phosphorylated at Y405.

Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous, Highest levels in heart, liver, skeletal muscle and ovary, lowest levels in brain, lung and kidney, Also found in B-cells, T-cells and endothelial cells,

Observed Band (KD): 49kD

Fields: Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Pathways in cancer

Function: Domain: The box 1 motif is required for JAK interaction and/or activation
Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding
Function: Binds IL13 with a low affinity. Together with IL4R-alpha can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for IL4 signaling, but cannot replace the function of gamma C in allowing enhanced IL2 binding activity
Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily
Subunit: Interleukin 13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1
Tissue Specificity: Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary, lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothe

Subcellular Location: Membrane, Single-pass type I membrane protein

Storage and Stability: -20°C/1 year

Gene Name: IL13RA1

Protein Name: Interleukin-13 receptor subunit alpha-1

Mouse Gene ID: 16164

Mouse SwissProt Number: O09030

Research Use Only