IL-1Beta Monoclonal Antibody - BT-MCA0768

IL-1Beta Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0768-50, BT-MCA0768-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Research Areas: Metabolism; Cardiovascular; Microbiology; Immunology

Target Protein: IL1B

Applications: WB, IHC-p, IF, ICC, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Interleukin-1 beta

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P01584; Mouse: P10749

Synonyms: IL1B; IL1F2; Interleukin-1 beta; IL-1 beta; Catabolin

GeneID: Human: 3553

Research Use Only