Product Description

IL-1R2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67514-50, BS67514-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: IL-1R2 is a type I transmembrane glycoprotein that is expressed predominantly by cells of the myeloid lineage. Like IL-1R1, the extracellμlar domain of IL-1R2 is capable of binding to all three forms of IL-1 . Unlike IL-1R1, however, membrane-bound IL-1R2 has a short cytoplasmic tail and does not transduce signals upon binding IL-1 but rather functions as a decoy receptor to dampen IL-1 signaling . As a negative regμlator of the IL-1 receptor signaling complex, research studies have also demonstrated that membrane-bound IL-1R2 undergoes regμlated intramembrane proteolysis in response to pro-inflammatory molecμles. This process converts the extracellμlar domain of IL-1R2 into a soluble decoy receptor capable of binding IL-1, limiting its capacity to elicit productive signals through membrane-bound IL-1R1 . Recent studies have demonstrated that some types of human cancers are enriched with regμlatory T cells that express high levels of IL-1R2, an attribute that may contribute to their role in immunosuppression .

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: IL1RB, Interleukin-1 receptor type 2, IL-1R-2, IL-1RT-2, IL-1RT2, CD121 antigen-like family member B, CDw121b, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, CD121b

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IL-1R2. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of IL-1R2 protein.

Molecular Weight: ~ 47 kDa

Pathway: NF-kB Signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P27930

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only