Product Description

IL-2Rβ (phospho Tyr364) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES5873-50, ES5873-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an up

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Applications: WB, ELISA

Alternate Names: IL2RB, Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, p70-75, p75, CD antigen CD122

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human IL-2R beta/CD122 around the phosphorylation site of Tyr364. AA range:331-380

Isotype: IgG

Target: IL-2Rβ

Specificity: Phospho-IL-2Rβ (Y364) Polyclonal Antibody detects endogenous levels of IL-2Rβ protein only when phosphorylated at Y364.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Lung,

Observed Band (KD): 75kD

Fields: Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Endocytosis, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Measles, Human T-cell leukemia virus 1 infection, Pathways in cancer, Transcriptional misregulation in cancer

Function: Domain: The box 1 motif is required for JAK interaction and/or activation
Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding
Function: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2
Similarity: Belongs to the type I cytokine receptor family. Type 4 subfamily
Similarity: Contains 1 fibronectin type-III domain
Subunit: Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I

Subcellular Location: Cell membrane, Single-pass type I membrane protein

Storage and Stability: -20°C/1 year

Gene Name: IL2RB

Protein Name: Interleukin-2 receptor subunit beta

Mouse Gene ID: 16185

Mouse SwissProt Number: P16297

Rat Gene ID: 25746

Rat SwissProt Number: P26896

Research Use Only